Current Issue

DOI:10.55841/1728-791X-2025.1.44-4

Pages 4-15

The transition to a sustainable energy future necessitates the advancement of green hydrogen production, with electrolysis emerging as a cornerstone technology. This paper provides a comprehensive analysis of Alkaline Water Electrolysis (AWE) and Proton Exchange Membrane (PEM) electrolysis, highlighting their efficiencies, limitations, and recent innovations. AWE offers cost-effective scalability but faces challenges like low current densities and gas crossover. In contrast, PEM electrolysis excels in high-purity hydrogen production and rapid response to fluctuating renewable energy inputs but is limited by high costs due to noble metal catalysts. Recent breakthroughs in catalyst design, such as nanostructured and bifunctional materials, have significantly enhanced efficiency and durability while reducing reliance on expensive materials. The integration of electrolysis technologies with renewable energy systems, supported by strategic investments and policy frameworks, is essential for scaling green hydrogen production globally. This study emphasizes the importance of continuous innovation and collaboration to overcome existing challenges and accelerate the adoption of green hydrogen.

DOI:10.55841/1728-791X-2025.1.44-16

Pages 16-22

The pathologic mechanism of Alzheimer's disease (AD) is also associated with deficits in cholinergic transmission, so cholinesterase inhibitors (ChIs) are key agents in symptomatic therapy. However, existing cholinomimetics are limited by side effects, particularly with hepatotoxicity. In this regard, the search for new therapeutic agents exhibiting minimal side effects is relevant. Modern in silico methods allow efficient selection and analysis of promising compounds at the stage of preclinical studies. In this work, the interactions of top-5 pre-selected N-N-disubstituted piperazines with acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) were studied using computational approaches.

DOI:10.55841/1728-791X-2025.1.44-23

Pages 23-26

In the present paper, we consider some methods for describing the motion of a body along a line, among which approximation methods using a finite difference scheme are discussed. Here, the principal task will be the modeling of a body’s movement according to a position record over some time interval, while the discussion will be focused on an investigation of how these discrete observations of a body’s position may be used in obtaining a continuous function of motion.